Methyl 1-(2,2-diMethylpropanoyl)piperidine-4-carboxylate synthesis
- Product Name:Methyl 1-(2,2-diMethylpropanoyl)piperidine-4-carboxylate
- CAS Number:505088-49-3
- Molecular formula:C12H21NO3
- Molecular Weight:227.3
7462-86-4
143 suppliers
$11.00/10g
3282-30-2
356 suppliers
$19.85/100ml
505088-49-3
10 suppliers
$65.00/100mg
Yield:505088-49-3 77%
Reaction Conditions:
Stage #1: methyl piperidine-4-carboxylate hydrochloridewith N-ethyl-N,N-diisopropylamine in dichloromethane; for 0.166667 h;
Stage #2: pivaloyl chloride in dichloromethane at 20;
Steps:
18
Example 18 General Procedure for the Reaction of Methyl Piperidine-4-carboxylate hydrochloride with Acid Chlorides[0150] To a suspension of methyl piperidine-4-carboxylate hydrochloride (5.6 mmol) in CH2CI2 (20 mL) at 0 °C was added diisopropylethyl amine (16.7 mmol) and the suspension was stirred for 10 minutes. Appropriate acid chloride (8.4 mmol) was added dropwise and the solution was allowed to warm to rt and stirred overnight. The reaction was diluted with water (15 mL) and CH2CI2 (15 mL). The organic layer was collected and the aqueous layer was extracted with CH2CI2 (2 x 20 mL). The combined organic extracts were dried ( a2S04) and concentrated under reduce pressure to afford the following compounds.
References:
WO2012/142237,2012,A1 Location in patent:Page/Page column 100
2971-79-1
281 suppliers
$10.00/10g
3282-30-2
356 suppliers
$19.85/100ml
505088-49-3
10 suppliers
$65.00/100mg