5-METHYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:5-METHYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:51135-70-7
- Molecular formula:C11H12N2O2
- Molecular Weight:204.23
13061-96-6
295 suppliers
$6.00/1g
885276-93-7
115 suppliers
$36.00/100mg
51135-70-7
35 suppliers
inquiry
Yield:51135-70-7 77%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;caesium carbonate in N,N-dimethyl-formamide at 100; for 2 h;
Steps:
449.a Example 449 step a:
A solution of ethyl 5-bromopyrazolo[1,5-ajpyridine-3-carboxylate (1.0 g, 3.73 mmol),methylboronic acid (448 mg, 7.46 mmol), Pd(dppf)C12 (545 mg, 0.746 mmol) and C52CO3(2.42 g, 7.46 mmol) was dissolved in DMF (5.0 mL), then the mixture was stirred at 100 °Cfor two hours. It was concentrated, and purified by silica gel chromatography with PE:EA=5: 1to obtain the desired compound as an orange solid (589 mg, 77%). ESI MS m/z = 204.5[M+Hj.
References:
WO2017/15449,2017,A1 Location in patent:Page/Page column 342
108-89-4
319 suppliers
$14.00/25mL
38202-27-6
157 suppliers
$6.00/1g
105-37-3
383 suppliers
$10.00/5mL
51135-70-7
35 suppliers
inquiry
108-89-4
319 suppliers
$14.00/25mL
51135-70-7
35 suppliers
inquiry