5-(aminomethyl)furan-2-carboxylic acid hydrochloride synthesis

6synthesis methods

Product Name:5-(aminomethyl)furan-2-carboxylic acid hydrochloride
CAS Number:51521-95-0
Molecular formula:C6H8ClNO3
Molecular Weight:177.5856

934-65-6 Synthesis

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5-(aminomethyl)furan-2-carboxylic acid hydrochloride

51521-95-0
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Yield:51521-95-0 100%

Reaction Conditions:

with hydrogenchloride in water;

Steps:

2.1 4.2.1 5-(Aminomethyl)furan-2-carboxylic acid hydrochloride (4a)

5-(Aminomethyl)furan-2-carboxylic acid (25.0 mg, 0.18 mmol) was dissolved in 2 N HCl (5 mL) followed by solvent removal under reduced pressure. This was repeated twice to yield 5-(aminomethyl)furan-2-carboxylic acid hydrochloride as an off white powder (31.5 mg, 100%). ¹H NMR (500 MHz, MeOD) δ 7.22 (d, J = 3.3 Hz, 1H), 6.71 (d, J = 3.3 Hz, 1H), 4.25 (s, 2H). ¹³C NMR (126 MHz, MeOD) δ 161.27, 152.05, 147.49, 119.76, 113.69, 36.80. HRMS (ESI): Calcd for C₆H₇NO₃ [M-H]^- 140.0353; found 140.0343.

References:

Hawker, Dustin D.;Silverman, Richard B. [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 19,p. 5763 - 5773]