Benzaldehyde, 4-[4-chloro-3-(trifluoromethyl)phenoxy]- synthesis
1synthesis methods
- Product Name:Benzaldehyde, 4-[4-chloro-3-(trifluoromethyl)phenoxy]-
- CAS Number:516481-95-1
- Molecular formula:C14H8ClF3O2
- Molecular Weight:300.66
Yield:516481-95-1 100%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 120; for 0.333333 h;Microwave irradiation;
Steps:
D20: 4- { [4-Chloro-3-(trifluoromethyl)phenyl] oxy}benzaldehydeThe mixture of 4-chloro-3-(trifluoromethyl)phenol (3.2g, 16.28 mmol), 4-fluorobenz aldehyde (2.425 g, 19.54 mmol) and K2C03 (3.38 g, 24.42 mmol) in DMF(25 mL) was heated with a microwave reactor at 120°C for 20 min. Purification via an ISCO system then afforded the title compound as a yellow solid (4.9g, 100 % yield). LCMS: rt =3.78 min, [M+H+] =300.9
References:
WO2012/76435,2012,A1 Location in patent:Page/Page column 33