ChemicalBook CAS DataBase List Ethyl 5-methoxy-1,2-dimethyl-4-nitroindole-3-carboxylate

Ethyl 5-methoxy-1,2-dimethyl-4-nitroindole-3-carboxylate synthesis

5synthesis methods

Product Name:Ethyl 5-methoxy-1,2-dimethyl-4-nitroindole-3-carboxylate
CAS Number:52535-61-2
Molecular formula:C14H16N2O5
Molecular Weight:292.29

40963-98-2 Synthesis

ethyl 5-methoxy-1,2-dimethylindole-3-carboxylate

40963-98-2
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Ethyl 5-methoxy-1,2-dimethyl-4-nitroindole-3-carboxylate

52535-61-2
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Yield:-

Reaction Conditions:

with nitric acid;acetic acid at 0 - 20; for 2 h;

Steps:

24B Synthesis of quinone 2

To a solution of 20 g (81 mmol, 1 eq.) ethyl 5-methoxy-1,2-dimethyl-1H-indole-3- carboxylate in acetic acid (200 mL), cooled to 0°C was added a mixture of nitric acid (4.6 mL) and acetic acid (20 mL). The mixture was then stirred at rt for 2 h. A yellow suspension was obtained which was poured on to an ice-water mixture and the crystals obtained were filteredoff and dried. Crude product was purified by flash chromatography to afford product as a yellow solid (14.0 g, 59.3%)

References:

WO2018/31662,2018,A1 Location in patent:Page/Page column 177; 178

40963-98-2 Synthesis

40963-98-2
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