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4-Pyridinecarboxylic acid, 2,6-diMethoxy-, Methyl ester synthesis

6synthesis methods
-

Yield:52606-00-5 76 %

Reaction Conditions:

Stage #1: methanol;sodium methylate;2,6-dichloropyridine-4-carboxylic acid at 145;Microwave irradiation;
Stage #2: with sulfuric acidReflux;

References:

Barbaro, Lisa;Nagalingam, Gayathri;Triccas, James A.;Tan, Lendl;West, Nicholas P.;Priebbenow, Daniel L.;Baell, Jonathan B. [ChemMedChem,2023,vol. 18,# 1,art. no. E202200533] Location in patent:supporting information

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