ChemicalBook CAS DataBase List 2-(3-hydroxypropyl)-6-[(3-hydroxypropyl)amino]-1H-benz[de]isoquinoline-1,3(2H)-dione

2-(3-hydroxypropyl)-6-[(3-hydroxypropyl)amino]-1H-benz[de]isoquinoline-1,3(2H)-dione synthesis

6synthesis methods

Product Name:2-(3-hydroxypropyl)-6-[(3-hydroxypropyl)amino]-1H-benz[de]isoquinoline-1,3(2H)-dione
CAS Number:52821-24-6
Molecular formula:C18H20N2O4
Molecular Weight:328.36

1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-bromo-2-(3-hydroxypropyl)-

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2-(3-hydroxypropyl)-6-[(3-hydroxypropyl)amino]-1H-benz[de]isoquinoline-1,3(2H)-dione

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Yield:52821-24-6 80%

Reaction Conditions:

in N,N-dimethyl-formamide at 90; for 4 h;

Steps:

Procedure for the synthesis of 10a-10e:

General procedure: A solution ofappropriate compounds 7a-7e (2 mmol) and amine alcohol(2 mmol) in anhydrous DMF (20 ml) was stirred and heatedat 90°C for about 4 h. After total consumption of substrates,as indicated by TLC (10% MeOH:CHCl3), the mixture waspoured into water (50 ml), the precipitate was filtered off,washed with distilled water and recrystallized from absoluteethanol to give product of high purity.

References:

Kasprzycki, Przemys?aw;Strama, Klaudia;Tomczyk, Mateusz D.;Walczak, Krzysztof Z.;Wawszków, Martyna;Wyrostek, Anna Byczek [Medicinal Chemistry,2019,vol. 15,# 5,p. 550 - 560]

4053-08-1 Synthesis