ChemicalBook CAS DataBase List (8-(benzyloxy)-5-[(1R)-2-broMo-1-{[tert-butyl(diMethyl)silyl]oxy}ethyl]quinolin-2(1H)-one )

(8-(benzyloxy)-5-[(1R)-2-broMo-1-{[tert-butyl(diMethyl)silyl]oxy}ethyl]quinolin-2(1H)-one ) synthesis

12synthesis methods

Product Name:(8-(benzyloxy)-5-[(1R)-2-broMo-1-{[tert-butyl(diMethyl)silyl]oxy}ethyl]quinolin-2(1H)-one )
CAS Number:530084-74-3
Molecular formula:C24H30BrNO3Si
Molecular Weight:488.49

530084-79-8 Synthesis

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone

530084-79-8
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18162-48-6 Synthesis

18162-48-6
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(8-(benzyloxy)-5-[(1R)-2-broMo-1-{[tert-butyl(diMethyl)silyl]oxy}ethyl]quinolin-2(1H)-one )

530084-74-3
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Yield:530084-74-3 99.3%

Reaction Conditions:

with triethylamine in dichloromethane at 0 - 20;

Steps:

1 8-benzyloxy-5-((R)-2-bromo-1-(tert-butyldimethylsilyl)oxy-ethyl)-1H-quinolin-2-one synthesis (compound of formula IV)

50 g of the compound of formula III was added to a 1000 mL three-necked flask, 600 ml of dichloromethane, dissolved at room temperature, dissolved, and then added with 17 g of triethylamine, cooled to 0 ° C in an ice bath, and tert-butyldimethylchlorosilane was added dropwise with stirring. 24.8g, after adding, return to normal temperature reaction for 2~4h. After the reaction was completed, it was cooled to 0 ° C, and the solution was slowly added dropwise to a solution of IN HCl, and the layers were separated. The aqueous phase was extracted with 200 ml of dichloromethane.Concentrated to obtain 78g of the target compound,The yield is 99.3%

References:

CN110128339,2019,A Location in patent:Paragraph 0030-0032

530084-79-8 Synthesis

530084-79-8
138 suppliers
$16.00/100mg