ChemicalBook CAS DataBase List (R)-N-(5-Cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonaMide

(R)-N-(5-Cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonaMide synthesis

5synthesis methods

Product Name:(R)-N-(5-Cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonaMide
CAS Number:530145-62-1
Molecular formula:C21H19N3O5S2
Molecular Weight:457.52

96784-54-2 Synthesis

96784-54-2
120 suppliers
$7.00/250mg

(R)-N-(5-Cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonaMide

530145-62-1
8 suppliers
inquiry

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 7 h / UV-irradiation
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: pyridine; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane
4.1: tetrahydrofuran / 12 h / 20 - 30 °C / Inert atmosphere; Large scale
4.2: Large scale

References:

Shi, Zhongping;Fan, Junying;Kronenthal, David R.;Mudryk, Boguslaw M. [Organic Process Research and Development,2018,vol. 22,# 11,p. 1534 - 1540]