2H-Isoindole-2-acetyl chloride, 1,3-dihydro-α-methyl-1,3-dioxo-, (αR)- synthesis
- Product Name:2H-Isoindole-2-acetyl chloride, 1,3-dihydro-α-methyl-1,3-dioxo-, (αR)-
- CAS Number:53100-40-6
- Molecular formula:C11H8ClNO3
- Molecular Weight:237.64
29588-83-8
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Yield:53100-40-6 98.1%
Reaction Conditions:
with thionyl chloride for 4 h;Reflux;
Steps:
1.2 (2) Synthesis of compound 3-1 ((R)-2-(1,3-dioxoisoindolin-2-yl)propionyl chloride):
add 400 mL thionyl chloride and 1 mol to a 1 L single-neck flask Compound 2-1 was subjected to acyl chloride reaction under heating and refluxing conditions for 4 h, excess thionyl chloride was recovered, and cooled to room temperature to obtain compound 3-1 (off-white solid, 233.12 g, yield 98.1%). The structural characterization data of compound 3-1 are shown in Table 2.
References:
CN114014793,2022,A Location in patent:Paragraph 0121; 0124
85-44-9
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