4-CHLORO-1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE synthesis

10synthesis methods

Product Name:4-CHLORO-1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE
CAS Number:5334-59-8
Molecular formula:C11H6Cl2N4
Molecular Weight:265.1

5334-29-2 Synthesis

1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL

5334-29-2
20 suppliers
$117.00/1mg

4-CHLORO-1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE

5334-59-8
26 suppliers
$280.00/100mg

Yield:5334-59-8 97%

Reaction Conditions:

with trichlorophosphate for 24 h;Reflux;

Steps:

5.1.3. General procedure for preparing 4-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidines (19-24)

General procedure: To 0.004 mol of derivatives 13-18 was added 10 mL of phosphorus oxychloride. The mixture stirred under reflux for 24 h. Excess solvent was removed under reduced pressure, and the resulting material was carefully added to 50 mL of crushed ice. The mixture was then basified to pH 7 with aqueous NaOH (6 M) and stirred for 40 min. The mixture was diluted with water (30 mL) and extracted with chloroform(3×30 mL). The combined organic solution was washed with water(3×50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum to produce 19-24 in 78-97% yield.

References:

Feitosa, Livia M.;da Silva, Edson R.;Hoelz, Lucas V.B.;Souza, Danielle L.;Come, Julio A.A.S.S.;Cardoso-Santos, Camila;Batista, Marcos M.;Soeiro, Maria de Nazare C.;Boechat;Pinheiro, Luiz C.S. [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 14,p. 3061 - 3069]

1073-70-7 Synthesis