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ChemicalBook CAS DataBase List 2-OXO-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-SULFONYL CHLORIDE
53439-87-5

2-OXO-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-SULFONYL CHLORIDE synthesis

2synthesis methods
-

Yield: 77%

Reaction Conditions:

with chlorosulfonic acid at 20; for 1.5 h;Cooling with ice;

Steps:

2.1 (1) 2-oxo-2,3-dihydro-1H-benzo [d] imidazole-5-sulfonyl chloride
To a solution of chlorosulfonic acid (13 mL), 2-hydroxybenzimidazole (8.00 g, 41.2 mmol) was added in 10 portions under ice-cooling over 1 hour. After stirring for 30 minutes at room temperature, the reaction mixture was added to water under ice cooling. The reaction mixture was filtered, washed with water and dried under reduced pressure to give the title compound (10.8 g, 77%).

References:

Hyogo College of Medicine;Osaka university;Tsujikawa, Kazutake;Inoe, Gou;Taisuke, Nakayama;Tanaka, Akihito;Tokoro, Miyuki;Shimizu, Tadashi JP2019/52096, 2019, A Location in patent:Paragraph 0125; 0126; 0127