1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione synthesis

8synthesis methods

Product Name:1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
CAS Number:5401-15-0
Molecular formula:C6H6N4O2
Molecular Weight:166.14

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1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

5401-15-0
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Yield:5401-15-0 92%

Reaction Conditions:

in toluene;Product distribution / selectivity;Reflux;

Steps:

1

Alternatively, a mixture of 5 -amino- 1 -methyl- lH-pyrazolo-4-carboxylic acid amide 3 (700 mg, 5.00 mmol) and oxalyl chloride (1.2 equiv., 0.5 ml) in dry toluene (20 ml) was refluxed overnight. The reaction mixture was cooled down, precipitate filtered, washed with diethyl ether and dried to give l-methyl-l,7-dihydro-pyrazolo[3,4-t/]pyrimidine-4, 6-dione 4 (765 mg, 92%).

References:

WO2009/97446,2009,A1 Location in patent:Page/Page column 65