3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide synthesis

Yield:-

Reaction Conditions:

at 150; for 8 h;Temperature;

Steps:

1.1
1) to a three-necked flask equipped with a reflux device, followed by adding an equimolar amount of thiazole and ethyl bromide,And acetoin as a solvent, refluxed at 150 oil bath for 28h,Continue stirring until the reaction mixture was cooled to room temperature, the solvent was recovered by rotary evaporation, the remaining reaction was allowed to stand 8h,Suction filtration, acetoin washing to give a white solid,Acetoin was recrystallized and dried in a vacuum oven at 50 ° C to give 3-ethyl-4-methyl-5-hydroxyethylthiazole bromide.

References:

Huaiyin Technology College;He Lei;Huang Qiuyue;Yun Shan;Guo Tan;Hong Kun;Zhu Xiufang;Zhang Jiadong;Chen Jing;Wang Chaoyu;Xu Ying CN107188793, 2017, A Location in patent:Paragraph 0023; 0027; 0031

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