3-(N-Benzyl-N-methylamino)propiophenone hydrochloride synthesis
- Product Name:3-(N-Benzyl-N-methylamino)propiophenone hydrochloride
- CAS Number:5409-62-1
- Molecular formula:C17H20ClNO
- Molecular Weight:289.7998
50-00-0
846 suppliers
$10.00/25g
98-86-2
743 suppliers
$9.00/5g
103-67-3
420 suppliers
$5.00/10g
5409-62-1
21 suppliers
inquiry
Yield:5409-62-1 90%
Reaction Conditions:
with hydrogenchloride in water;isopropyl alcohol for 6 h;Heating / reflux;
Steps:
1
Example 1; 3-Benzylmethylamino-l-phenyl-l-propanone hydrochloride (V); Aqueous concentrated HCl is added dropwise to a solution of benzylmethylamine (129.1 ml) in 2-propanol (600 ml). Then, paraformaldehyde (39.64 g) and acetophenone (116.7 ml) are added. The mixture is refluxed for 6 hours. After gradual cooling down to 0 0C, the mixture is stirred for 1 hour. Precipitated crystals are sucked off and washed with 2-propanol. The yield was 261 g (90 %) of substance V.
References:
ZENTIVA, A.S. WO2007/9405, 2007, A1 Location in patent:Page/Page column 9
50-00-0
846 suppliers
$10.00/25g
13426-94-3
23 suppliers
$199.00/500mg
98-86-2
743 suppliers
$9.00/5g
5409-62-1
21 suppliers
inquiry
622-29-7
78 suppliers
$22.00/1g
5409-62-1
21 suppliers
inquiry