![](/CAS/GIF/54346-33-7.gif)
8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE synthesis
- Product Name:8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE
- CAS Number:54346-33-7
- Molecular formula:C6H4BrClN4S
- Molecular Weight:279.54
![8-Bromo-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-ol](/CAS/GIF/54346-35-9.gif)
54346-35-9
14 suppliers
$320.00/500mg
![8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE](/CAS/GIF/54346-33-7.gif)
54346-33-7
23 suppliers
$410.00/500mg
Yield:54346-33-7 600 mg
Reaction Conditions:
with N,N-dimethyl-aniline;trichlorophosphate at 130; for 4 h;
Steps:
111.5 [00738] Step 5: 8-Bromo-4-chloro-2-methylsulfanylpyrazolo[1,5-a] [1,3,5]triazine
A suspension of 8-bromo-2-methylsulfanyl-3H-pyrazolo[l,5-a][l,3,5]triazin-4-one (2.0 g, 6.13 mmol, 1 eq) and N,N-dimethylaniline (742.58 mg, 6.13 mmol, 776.76 μ_, 1 eq) in POCb (16.50 g, 107.61 mmol, 10 mL, 17.56 eq) was stirred at 130 °C for 4 h. The mixture was added into water (100 mL) at 0 °C, extracted with EtOAc (200 mL x 3). The combined organic layers were washed with brine (50 mL), dried over Na2S04, filtered and concentrated. The crude material was purified on silica gel column chromatography (from pure PE to PE/EtOAc = 3/1, TLC: PE/EtOAc = 3/1, Rf = 0.8) to yield 8-bromo-4-chloro-2-methylsulfanyl-pyrazolo[l,5-a][l,3,5]triazine (600 mg, 2.08 mmol, 33.9% yield, 97% purity) as a white solid. NMR (400 MHz, CDCb) δ ppm 8.12 (s, 1H), 2.66 (s, 3H); ES-LCMS m/z 278.9, 280.9 [M+H]+.
References:
WO2018/195397,2018,A2 Location in patent:Paragraph 00733; 00738
![4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE](/CAS/GIF/54346-19-9.gif)
54346-19-9
89 suppliers
$78.00/50mg
![8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE](/CAS/GIF/54346-33-7.gif)
54346-33-7
23 suppliers
$410.00/500mg
![8-Bromo-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-ol](/CAS/GIF/54346-35-9.gif)
54346-35-9
14 suppliers
$320.00/500mg
![8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE](/CAS/GIF/54346-33-7.gif)
54346-33-7
23 suppliers
$410.00/500mg
![8-Bromo-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-ol](/CAS/GIF/54346-35-9.gif)
54346-35-9
14 suppliers
$320.00/500mg
![N,N-Dimethylaniline](/CAS/GIF/121-69-7.gif)
121-69-7
524 suppliers
$10.00/25mL
![8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE](/CAS/GIF/54346-33-7.gif)
54346-33-7
23 suppliers
$410.00/500mg
![ethyl 2H-pyrazol-3-ylaMinocarbothioylcarbaMate](/CAS/20150408/GIF/34683-00-6.gif)
34683-00-6
1 suppliers
inquiry
![8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE](/CAS/GIF/54346-33-7.gif)
54346-33-7
23 suppliers
$410.00/500mg