7-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester synthesis

6synthesis methods

Product Name:7-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
CAS Number:5435-82-5
Molecular formula:C12H12N2O3
Molecular Weight:232.24

1603-41-4
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87-13-8
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$5.00/5g

7-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

5435-82-5
16 suppliers
$230.00/1g

Yield:5435-82-5 58%

Reaction Conditions:

with 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile at 150; for 0.333333 h;Microwave (CEM);

Steps:

236.1

A mixture of diethyl 2-(ethoxymethylene)malonate (0.60 g, 3 mmol), 5-methylpyridin-2-amine (0.20 g, 2 mmol), DBU (0.1 ml, 0.9 mmol) in acetonitrile (2 g, 49 mmol) was heated under Microwave (CEM) at 150⁰C (150 W) for 20 min. The resultant was diluted with dichloromthane and water, and the organic layer was dried over sodium sulfate. The organic solution was concentrated, and the residue was crystallized in dichloromethane and diethyl ether to give the title compound as a pale yellow solid (0.25 g, 58 %): MS (ESI pos. ion) m/z: 233 (MH+). Calc'd exact mass for Ci₂H₁₂N₂O₃: 232.

References:

WO2006/116713,2006,A1 Location in patent:Page/Page column 208

((5-METHYL-2-PYRIDINYLAMINO)METHYLENE)MALONIC ACID DIETHYL ESTER

19056-89-4
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inquiry

5435-82-5
16 suppliers
$230.00/1g

References

87-13-8
429 suppliers
$5.00/5g

5435-82-5
16 suppliers
$230.00/1g

References

1603-41-4
532 suppliers
$7.00/25g

5435-82-5
16 suppliers
$230.00/1g

References

19056-89-4
6 suppliers
inquiry

5435-82-5
16 suppliers
$230.00/1g

23443-20-1
10 suppliers
$90.00/50mg

References