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3-(3-chloro-4-hydroxy-5-methoxy-phenyl)prop-2-enoic acid synthesis

2synthesis methods
19463-48-0 Synthesis
5-CHLOROVANILLIN

19463-48-0
104 suppliers
$24.00/1g

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Yield:5438-40-4 75.9%

Reaction Conditions:

with pyridine;aniline in toluene; for 2 h;Reflux;

References:

Xia, Chun-nian;Li, Hai-bo;liu, Feng;Hu, Wei-xiao [Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,# 24,p. 6553 - 6557] Location in patent:supporting information; experimental part