Benzeneethanimidicacid, ethyl ester, hydrochloride (1:1) synthesis
- Product Name:Benzeneethanimidicacid, ethyl ester, hydrochloride (1:1)
- CAS Number:5442-34-2
- Molecular formula:C10H13NO.ClH
- Molecular Weight:199.6773
Yield:5442-34-2 99%
Reaction Conditions:
with hydrogenchloride at 0 - 20; for 12 h;Inert atmosphere;
Steps:
B2
2-Phenylacetonitrile was dissolved in anhydrous ethanol (2 mL) under an atmosphere of Ar. The solution was cooled to 0 °C, saturated with HC1 gas, stirred for 6 h, allowed to warm to RT, and stirred for 6 h. The solvent was removed in vacuo to afford ethyl 2- phenylacetimidate hydrochloride (1.7 g, 99 %) as a white solid. H NMR (400 MHz, DMSO-i: δ 7.36-7.35 (m, 5 H), 4.39 (q, J = 7.0 Hz, 2 H), 3.99 (s, 2 H), 1.26 (t, J = 7.0 Hz, 3 H).
References:
WO2014/145023,2014,A1 Location in patent:Paragraph 0383
140-29-4
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$19.00/25mL
5442-34-2
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$677.15/1g
