![](/CAS/20200515/GIF/5622-83-3.gif)
Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro- (6CI,7CI,8CI,9CI) synthesis
- Product Name:Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro- (6CI,7CI,8CI,9CI)
- CAS Number:5622-83-3
- Molecular formula:C11H12N2
- Molecular Weight:172.23
Yield:5622-83-3 75%
Reaction Conditions:
Stage #1: piperidin-2-one;o-nitroiodobenzenewith caesium carbonate;palladium(II) trifluoroacetate;2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl in toluene at 80; for 18 h;
Stage #2: with iron;acetic acid in toluene; for 0.5 h;Heating / reflux;
Stage #3: with sodium hydrogencarbonate in water;Product distribution / selectivity;
Steps:
9
Method A applied to 1-lodo-2-nitrobenzene (125 mg, 0.5 mmol) and piperidin-2-one (59 mg, 0.6 mmol) afforded the title compound as pale yellow solid (65 mg, 75%). mp 104-1060C. 1H NMR (DMSO) δ 1.98-2.07 (m, 4 H), 3.16-3.23 (m, 2 H), 4.30 (t, J = 6.9 Hz, 2 H)1 7.51-7.56 (m, 2 H), 7.75-7.92 (m, 2 H); 13C NMR δ 17.7, 20.5, 22.3, 43.0,
References:
WO2009/412,2008,A1 Location in patent:Page/Page column 30-31
![2-Benzimidazolebutanol(7CI,8CI)](/CAS/GIF/2453-51-2.gif)
2453-51-2
6 suppliers
inquiry
![Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro- (6CI,7CI,8CI,9CI)](/CAS/20200515/GIF/5622-83-3.gif)
5622-83-3
7 suppliers
inquiry
![Piperidine, 1-(2-iodophenyl)-](/CAS/20210305/GIF/1415808-72-8.gif)
1415808-72-8
0 suppliers
inquiry
![Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro- (6CI,7CI,8CI,9CI)](/CAS/20200515/GIF/5622-83-3.gif)
5622-83-3
7 suppliers
inquiry
![1-(2-NITROPHENYL)PIPERIDINE](/CAS/GIF/15822-77-2.gif)
15822-77-2
38 suppliers
$28.60/250mg
![Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro- (6CI,7CI,8CI,9CI)](/CAS/20200515/GIF/5622-83-3.gif)
5622-83-3
7 suppliers
inquiry