ChemicalBook CAS DataBase List 3-Amino-3-iminopropanoic acid ethyl ester hydrochloride

3-Amino-3-iminopropanoic acid ethyl ester hydrochloride synthesis

4synthesis methods

Product Name:3-Amino-3-iminopropanoic acid ethyl ester hydrochloride
CAS Number:57508-48-2
Molecular formula:C5H11ClN2O2
Molecular Weight:166.61

27317-59-5
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$250.00/5g

3-Amino-3-iminopropanoic acid ethyl ester hydrochloride

57508-48-2
129 suppliers
$12.00/1g

Yield:57508-48-2 78%

Reaction Conditions:

with ammonium chloride in ethanol at 120; for 1 h;Microwave irradiation;

Steps:

ethyl 3-amino-3-iminopropionate hydrochloride (6*HCl)
A solution of ethyl 3-amino-3-ethoxypropenoate 10 (760 mg, 4.78 mmol) and NH4Cl (270 mg, 5.0 mmol) in EtOH (4.0 mL) was irradiated in a pressure-rated glass tube (10 mL) at 120 °C for 1 h (hold-time) using a CEM Discover microwave synthesizer by moderation of the initial magnetron power (200 W). After cooling in a flow of compressed air, the solution was filtered, evaporated in vacuo and triturated with diethylether to give the title compound1 (923 mg, 78%) as a colourless solid, which was used without further purification; νmax (neat) /cm-1 3300, 3095,1738, 1687; δH (500 MHz; d6-DMSO) /ppm 9.16 (2H, bs, NHH), 8088 (2H, bs, 2H, NHH), 4.15 (2H, q, J = 7.1 Hz, OCH2), 3.63 (2H, s, 2-H),1.22 (3H, t, J = 7.1 Hz, Me); δC (125 MHz, d6-DMSO) /ppm 166.7 (C), 163.6 (C), 61.9 (CH2), 38.2 (CH2), 14.4 (Me); m/z (EI) 130 (M•+).

References:

Bagley, Mark C.;Alnomsy, Ayed;Temple, Scott J. [Synlett,2016,vol. 27,# 11,art. no. ST-2016-D0098-L,p. 1728 - 1732] Location in patent:supporting information

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