ChemicalBook CAS DataBase List (2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER synthesis

5synthesis methods

Product Name:(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
CAS Number:57561-39-4
Molecular formula:C8H17NO3
Molecular Weight:175.23

109-83-1
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24424-99-5 Synthesis

24424-99-5
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(2-HYDROXYETHYL)METHYLCARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

57561-39-4
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Yield:57561-39-4 100%

Reaction Conditions:

in dichloromethane at 20; for 1 h;

Steps:

8.1 Step 1:
To a solution of 2-(methylamino)ethanol (500 mg, 0.53 ml, 6.66 mmol) in CH₂Cl₂ (20 ml) was added Boc₂O (1.48 g, 6.79 mmol), followed by stirring at room temperature for 1 hour. The reaction solution was extracted with brine and CH₂Cl₂. The organic layer thus obtained was dried over MgSO₄ and filtered. Then, the filtrate was concentrated in vacuo to obtain the object compound (colorless oil, quantitative); ¹H NMR (200 MHz, CDCl₃) δ 3.74 (q, J= 10.5, 5.2 Hz, 2H) 3.25 (t, J= 5.2 Hz, 2H) 2.91 (s, 3H) 1.45 (s, 9H); mass spectrum m/e (relative intensity) 144 (20) 102 (24) 57 (70) 44 (100).

References:

Korea Research Institute of Bioscience and Biotechnology;Korea Research Institute of Chemical Technology US2009/42872, 2009, A1 Location in patent:Page/Page column 19

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109-83-1
432 suppliers
$10.00/25ml