![](/CAS/20211123/GIF/58610-66-5.gif)
Spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-7'-acetic acid, 6'-cyano-α-ethyl-2',3'-dihydro-5'-oxo-, ethyl ester synthesis
- Product Name:Spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-7'-acetic acid, 6'-cyano-α-ethyl-2',3'-dihydro-5'-oxo-, ethyl ester
- CAS Number:58610-66-5
- Molecular formula:C17H20N2O5
- Molecular Weight:332.36
Yield:58610-66-5 95%
Reaction Conditions:
with potassium carbonate in acetonitrile at 85; for 3 h;
Steps:
30.2 Step (2):6-cyano-1,1-ethylenedioxy-7- (1′-ethoxycarbonyl) propyl-5-oxo-Δ6 (intermediate 8) -tetrahydroindolizine(Intermediate M8)Preparation
The synthesized M7 (20.00g, 65.64mmol) was dissolved in acetonitrile (300ml),Potassium carbonate (24.00 g, 172 mmol) and ethyl bromide (17.58 g, 162 mmol) were added in this order,The reaction was refluxed at 85 ° C for 3h, and the temperature was lowered to room temperature. The inorganic salt was removed by filtration.The filter residue was washed three times with acetonitrile,The filtrate was concentrated by rotary evaporation to obtain 21.82 g of khaki solid.Yield: 95%.
References:
CN110590796,2019,A Location in patent:Paragraph 0223-0227; 0230-0232
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