2-(6-Methoxy-naphthalen-1-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane synthesis
- Product Name:2-(6-Methoxy-naphthalen-1-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
- CAS Number:588717-94-6
- Molecular formula:C17H21BO3
- Molecular Weight:284.16
Yield:588717-94-6 88%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in 1,4-dioxane at 120; for 6 h;Inert atmosphere;
Steps:
5 Synthesis of intermediate (44)Reaction Formula 48
In a dry 2L three-necked flask,Charged 6-methoxy-1-bromonaphthalene23.7 g (100 mmol) and 27.9 g (110 mmol) of boronic acid pinacol ester,Using 500 ml of 1,4-dioxane as solvent,Pass nitrogen for 15 minutes,Then, 1.5 g (2% mol) of Pd (dppf) Cl2 and 29.4 g (300 mmol)Potassium acetate, heating to 120 ° C, reflux reaction for 6 hours, the end of the reaction, To the room temperature, add activated carbon, the silica gel short column, suction filter, the filtrate spin dry, chromatography column, the intermediate (44) 25.0g, yield For 88%.
References:
CN106892914,2017,A Location in patent:Paragraph 0275; 0276; 0277; 0278
22604-07-5
97 suppliers
$22.00/100mg
588717-94-6
6 suppliers
inquiry