ethyl 6-bromoH-pyrrolo[1,2-a]pyrazine-3-carboxylate synthesis
- Product Name:ethyl 6-bromoH-pyrrolo[1,2-a]pyrazine-3-carboxylate
- CAS Number:588720-62-1
- Molecular formula:C10H9BrN2O2
- Molecular Weight:269.09
153780-28-0
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588720-62-1
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Yield:588720-62-1 57%
Reaction Conditions:
with N-Bromosuccinimide in dichloromethane; for 1 h;
Steps:
17
[1194] To a solution of ethyl pyrrolo[1,2-a]pyrazine-3-carboxylate (0.60 g, 3.18 mmol) in CH2Cl2 (60 mL) is added N-bromosuccinimide (0.56 g, 3.18 mmol) in one portion. After 1 h, solvent is removed in vacuo and the crude solid purified using preparative HPLC (1% IPA/heptane (0-5 minutes) to 2% isocratic) to give a brown solid for ethyl 6-bromopyrrolo[1,2-a]pyrazine-3-carboxylate. Yield 57%. MS (ESI+) for C10H9BrN2O2 m/z 271.01 (M+H)+.
References:
US2003/236264,2003,A1 Location in patent:Page 56