2-bromo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone synthesis

3synthesis methods

Product Name:2-bromo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone
CAS Number:5896-66-2
Molecular formula:C12H13BrO
Molecular Weight:253.13

774-55-0 Synthesis

774-55-0
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$44.00/5g

2-bromo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone

5896-66-2
9 suppliers
$203.00/250mg

Yield:5896-66-2 89%

Reaction Conditions:

with bromine in methanol at 0 - 20; for 18.75 h;

Steps:

4.A

Example 4 - Preparation of 2-chloro-6-(5',6',78Metrahvdronaphthalen-2'- vnimidazoβ.l-blthiazole f Compound 25); A. Preparation of 2-bromo-l-(5',6',7',8'-tetrahydronaphthalen-2'- yl)ethanone; Bromine (0.63 mL, 12.3 mmol) was added to a stirred solution of l-(5',6',7',8'- tetrahydronaphthalen-2'-yl)ethanone (2.13 g, 12.3 mmol) in methanol (15 mL) at O⁰C and the resultant solution allowed to stir for 2.75 hours before the reaction mixture was diluted with water and allowed to warm to room temperature over 16 hours. After this time, the reaction mixture was extracted with ethyl acetate:40-60 petrol (v:v 3:1, x3) and the combined organic layers washed with 10% aqueous potassium carbonate solution, dried over MgSO₄ and concentrated in vacuo to furnish the crude product (2.755g, 89%).¹H NMR (DMSO) 7.68-7.71 (2H, m), 7.22 (IH, d, J 8.6Hz), 4.86 (2H, s), 2.78 (4H, br s), 1.73-1.77 (4H, m).

References:

WO2009/13477,2009,A1 Location in patent:Page/Page column 23-24

119-64-2
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$9.00/25g

598-21-0
311 suppliers
$10.00/10g

5896-66-2
9 suppliers
$203.00/250mg

References

119-64-2
341 suppliers
$9.00/25g

5896-66-2
9 suppliers
$203.00/250mg

References