5H-PYRROLO-[3,2-B:4,5-B']DIPYRIDINE synthesis

7synthesis methods

Product Name:5H-PYRROLO-[3,2-B:4,5-B']DIPYRIDINE
CAS Number:75449-34-2
Molecular formula:C10H7N3
Molecular Weight:169.18

1069137-31-0
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75449-34-2
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Yield:75449-34-2 55%

Reaction Conditions:

with triphenylphosphine in 1,2-dichloro-benzene at 180; for 24 h;Inert atmosphere;

Steps:

95 Example 95, Preparation of Compound 48

Add 2-(3-nitropyridin-2-yl)pyridine (4.06 g, 20.25 mmol) in a 250 ml one-neck flask andTriphenylphosphine (13.3 g, 50.65 mmol) solvent was taken in 100 ml of o-dichlorobenzene solvent. Under the protection of N2, the temperature was raised to 180 ° C and refluxed for 24 h.After the reaction is completed, the mixture is distilled under reduced pressure, and the reaction solvent is concentrated to 40 ml.The column was passed through dichloromethane and methanol (15:1) to give the product in 55% yield.

References:

CN109422743,2019,A Location in patent:Paragraph 0429; 0430; 0431

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75449-34-2
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References