5H-Pyrrolo[3,4-d]pyrimidine-5,7(6H)-dione (9CI) synthesis

Yield:56606-38-3 16 g

Reaction Conditions:

with urea in o-xylene; for 6 h;Reflux;

Steps:

1.1 (1) Synthesis of Compound 2

Fura[3,4-d] pyrimidine-5,7-dione was added 180 ml of o-xylene,Add 25g urea, Heating and stirring Reflux for 6 hours, Cooled to room temperature, filtered, then added with water and ethyl acetate for extraction, liquidation, drying, concentration to get crude The crude product was recrystallized to give 16 g of compound 2 6H-pyrrolo [3,4-d] pyrimidine-5,7-dione.

References:

CN107200744,2017,A Location in patent:Paragraph 0020-0022