6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine synthesis
- Product Name:6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine
- CAS Number:188416-28-6
- Molecular formula:C6H5BrClFN2
- Molecular Weight:239.47
137234-74-3
331 suppliers
$10.00/1g
188416-28-6
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$100.00/1g
Yield:188416-28-6 98%
Reaction Conditions:
with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in dichloromethane at 55; for 16 h;Temperature;
Steps:
1.S1-6.S1
S1. Put 1 equivalent of 4-chloro-6-ethyl-fluoropyrimidine, 1.06 equivalent of N-bromosuccinimide, 0.0 5 equivalent of azobisisobutyronitrile and 12.9 equivalent of dichloromethane in 55°C After the bromination reaction is carried out for 16 hours under the water bath condition at , separation and purification are carried out according to the existing conventional separation and purification methods to obtain the first intermediate.
References:
Guangdong Longfu Pharmaceutical Co., Ltd.;Wu Weijie;Zeng Wenbin;Ni Mingmin;Zhang Shengbin CN111704606, 2020, A Location in patent:Paragraph 0029-0031; 0035-0037; 0041-0043; 0047-0049; 0053
137234-85-6
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$420.61/1gm:
188416-28-6
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$100.00/1g
137234-87-8
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$9.00/1g
188416-28-6
184 suppliers
$100.00/1g
759-67-1
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$41.00/1g
188416-28-6
184 suppliers
$100.00/1g