6-((2-Chlorophenoxy)(phenyl)Methyl)Morpholin-3-one synthesis

2synthesis methods

Product Name:6-((2-Chlorophenoxy)(phenyl)Methyl)Morpholin-3-one
CAS Number:93886-33-0
Molecular formula:C17H16ClNO3
Molecular Weight:317.7668

17639-01-9
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6-((2-Chlorophenoxy)(phenyl)Methyl)Morpholin-3-one

93886-33-0
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: SOCl₂ / 16 h / Ambient temperature
2: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C
3: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux
4: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C
5: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C
6: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

References:

Melloni;Carniel;Della Torre;et al. [European Journal of Medicinal Chemistry,1984,vol. 19,# 3,p. 235 - 242]

Acetamide, 2-chloro-N-[3-(2-chlorophenoxy)-2-hydroxy-3-phenylpropyl]-

93852-41-6
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93886-33-0
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References