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6-(4-fluorophenyl)morpholin-3-one synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 1 h / 0 °C
2: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C

References:

Micheli, Fabrizio;Cremonesi, Susanna;Semeraro, Teresa;Tarsi, Luca;Tomelleri, Silvia;Cavanni, Paolo;Oliosi, Beatrice;Perdon, Elisabetta;Sava, Anna;Zonzini, Laura;Feriani, Aldo;Braggio, Simone;Heidbreder, Christian [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 4,p. 1329 - 1332]