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6-(4-nitrophenyl)pyridazin-3(2H)-one synthesis

3synthesis methods
Benzenebutanoic acid, α-hydroxy-4-nitro-γ-oxo-, ethyl ester

105537-48-2
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6-(4-nitrophenyl)pyridazin-3(2H)-one

105537-49-3
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Yield:105537-49-3 88%

Reaction Conditions:

with hydrazine hydrate in butan-1-ol; for 8 h;Heating;

References:

Wermuth, Camille-Georges;Bourguignon, Jean-Jacques;Schlewer, Gilbert;Gies, Jean-Pierre;Schoenfelder, Angele;et al. [Journal of Medicinal Chemistry,1987,vol. 30,# 2,p. 239 - 249]