![](/CAS/20150408/GIF/1419101-45-3.gif)
6,6-Difluoro-spiro[3.3]heptane-2-carboxylic acid synthesis
- Product Name:6,6-Difluoro-spiro[3.3]heptane-2-carboxylic acid
- CAS Number:1419101-45-3
- Molecular formula:C8H10F2O2
- Molecular Weight:176.16
![Methyl 6-oxospiro[3.3]heptane-2-carboxylate](/CAS/GIF/1138480-98-4.gif)
1138480-98-4
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$31.00/100mg
![6,6-Difluoro-spiro[3.3]heptane-2-carboxylic acid](/CAS/20150408/GIF/1419101-45-3.gif)
1419101-45-3
48 suppliers
$45.00/10mg
Yield:-
Steps:
Multi-step reaction with 2 steps
1: morpholinosulfur trifluoride; boron trifluoride diethyl etherate; triethylamine tris(hydrogen fluoride) / dichloromethane / 72 h / 5 - 20 °C / Inert atmosphere
2: lithium hydroxide / tetrahydrofuran; water / 12 h / 0 °C
References:
Chernykh, Anton V.;Feskov, Illia O.;Chernykh, Alla V.;Daniliuc, Constantin G.;Tolmachova, Nataliya A.;Volochnyuk, Dmitriy M.;Radchenko, Dmytro S. [Tetrahedron,2016,vol. 72,# 7,p. 1036 - 1041]
![Spiro[3.3]heptane-2-carboxylic acid, 6,6-difluoro-, phenylmethyl ester](/CAS/20200611/GIF/1447942-36-0.gif)
1447942-36-0
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![6,6-Difluoro-spiro[3.3]heptane-2-carboxylic acid](/CAS/20150408/GIF/1419101-45-3.gif)
1419101-45-3
48 suppliers
$45.00/10mg
![Spiro[3.3]heptane-2-carboxylic acid, 6-oxo-](/CAS/GIF/889944-57-4.gif)
889944-57-4
87 suppliers
$26.00/100mg
![6,6-Difluoro-spiro[3.3]heptane-2-carboxylic acid](/CAS/20150408/GIF/1419101-45-3.gif)
1419101-45-3
48 suppliers
$45.00/10mg
![benzyl 6-oxospiro[3.3]heptane-2-carboxylate](/CAS/20180702/GIF/1447942-35-9.gif)
1447942-35-9
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![6,6-Difluoro-spiro[3.3]heptane-2-carboxylic acid](/CAS/20150408/GIF/1419101-45-3.gif)
1419101-45-3
48 suppliers
$45.00/10mg
![1,1-Cyclobutanedicarboxylic acid, 3-oxo-, 1,1-bis(1-methylethyl) ester](/CAS/20150408/GIF/893724-10-2.gif)
893724-10-2
57 suppliers
$10.00/1g
![6,6-Difluoro-spiro[3.3]heptane-2-carboxylic acid](/CAS/20150408/GIF/1419101-45-3.gif)
1419101-45-3
48 suppliers
$45.00/10mg