6,7,8,9-tetrahydro-5H-carbazole-3-carbonitrile synthesis
- Product Name:6,7,8,9-tetrahydro-5H-carbazole-3-carbonitrile
- CAS Number:100723-77-1
- Molecular formula:C13H12N2
- Molecular Weight:196.25
Yield:100723-77-1 91%
Reaction Conditions:
with glacial acetic acid for 8 h;Reflux;
Steps:
General procedure for the synthesis of starting substrate tetrahydrocarbazoles (1a-1q, 1v)
General procedure: A substituted phenyl hydrazine. HCl (4.61 mmol) was added to the mixture of cyclohexanone (4.61 mmol) and acetic acid (15 ml) portion wise for 30 min. The mixture was then refluxed for 8 h and progress of reaction was monitored by thin layer chromatography. The reaction mixture was cooled and poured into crushed ice. The solid product was separated, filtered, dried and recrystallized from the methanol solvent.
References:
Dalvi, Bhakti A.;Lokhande, Pradeep D. [Tetrahedron Letters,2018,vol. 59,# 22,p. 2145 - 2149] Location in patent:supporting information
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