![](/CAS/GIF/16806-93-2.gif)
6,7-Dihydro-4(5H)-benzofuranone synthesis
- Product Name:6,7-Dihydro-4(5H)-benzofuranone
- CAS Number:16806-93-2
- Molecular formula:C8H8O2
- Molecular Weight:136.15
![Chloroacetaldehyde](/CAS/GIF/107-20-0.gif)
107-20-0
4 suppliers
$18.10/5ml
![1,3-Cyclohexanedione](/CAS/GIF/504-02-9.gif)
504-02-9
552 suppliers
$5.00/10g
![6,7-Dihydro-4(5H)-benzofuranone](/CAS/GIF/16806-93-2.gif)
16806-93-2
145 suppliers
$7.00/250mg
Yield:16806-93-2 82%
Reaction Conditions:
with potassium iodide;sodium hydroxide in water at 20; for 12 h;Cooling with ice;
Steps:
1.1 (1) Synthesis of 6,7-dihydro-4(5H)-benzofuranone
Add 1,3-cyclohexanedione (10.0 g, 89.18 mmol) to a 250 mL round bottom flask, dissolve in 60 mL of water, and add 35 mL of 20% sodium hydroxide solution under ice bath.Further, KI (2.9 g, 17.4 mmol) was added, and finally, 16 mL of a 40% aqueous solution of chloroacetaldehyde was slowly added dropwise, and the reaction was carried out at room temperature. After 12 hours, the material was completely reacted by TLC.Adding a mass fraction of 37.5% concentrated hydrochloric acid to pH=4, adding 100 mL of water, extracting with petroleum ether (100 mL×4), combining the organic phases, washing with saturated brine (100 mL×3), and finally using anhydrous sodium sulfate dry,The solvent was evaporated under reduced pressure to give a pale yellow liquid, i.e., 6,7-dihydro-4(5H)-benzofuranone, 10.0 g, yield 82%.
References:
Changzhou University;Ren Jie;Wang Wenbin;Zhang Meiju;Hu Kun;Li Lixia;Yuan Ling CN110128382, 2019, A Location in patent:Paragraph 0008; 0089-0091
![VINYLIDENE CHLORIDE](/CAS/GIF/75-35-4.gif)
75-35-4
172 suppliers
$20.00/5 g
![1,3-Cyclohexanedione](/CAS/GIF/504-02-9.gif)
504-02-9
552 suppliers
$5.00/10g
![6,7-Dihydro-4(5H)-benzofuranone](/CAS/GIF/16806-93-2.gif)
16806-93-2
145 suppliers
$7.00/250mg
![Chloroacetaldehyde](/CAS/GIF/107-20-0.gif)
107-20-0
4 suppliers
$18.10/5ml
![6,7-Dihydro-4(5H)-benzofuranone](/CAS/GIF/16806-93-2.gif)
16806-93-2
145 suppliers
$7.00/250mg
![Chloroacetaldehyde](/CAS/GIF/107-20-0.gif)
107-20-0
4 suppliers
$18.10/5ml
![1,3-Cyclohexanedione](/CAS/GIF/504-02-9.gif)
504-02-9
552 suppliers
$5.00/10g
![1,4-Dimethoxybenzene](/CAS/GIF/150-78-7.gif)
150-78-7
511 suppliers
$5.00/25g
![6,7-Dihydro-4(5H)-benzofuranone](/CAS/GIF/16806-93-2.gif)
16806-93-2
145 suppliers
$7.00/250mg
![2-Furanbutanoyl chloride](/CAS/20210111/GIF/66144-45-4.gif)
66144-45-4
0 suppliers
inquiry
![6,7-Dihydro-4(5H)-benzofuranone](/CAS/GIF/16806-93-2.gif)
16806-93-2
145 suppliers
$7.00/250mg