6,8-DIFLUORO-4-HYDROXYQUINOLINE synthesis

3synthesis methods

Product Name:6,8-DIFLUORO-4-HYDROXYQUINOLINE
CAS Number:243448-16-0
Molecular formula:C9H5F2NO
Molecular Weight:181.14

1,3-Dioxane-4,6-dione, 5-[[(3,5-difluorophenyl)amino]methylene]-2,2-dimethyl-

1071541-70-2
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243448-16-0
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Yield:-

Reaction Conditions:

in diphenylether at 200; for 0.333333 h;

Steps:

10.2 4-Hydroxy-6,8-difluoro-quinoline

Step 2:
4-Hydroxy-6,8-difluoro-quinoline
(5-[(3,5-Difluoro-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione, (52 g, 0.1837 μmol) was dissolved in diphenyl ether and refluxed for 20 min at 200° C.
On complete consumption of starting material (tlc), reaction mixture was cooled and diluted by hexane.
Solid obtained was filtered and washed with sufficient quantities of hexane to furnish product. Mass: 182.09 (M+1).

References:

US2014/336182,2014,A1 Location in patent:Paragraph 0343

2033-24-1 Synthesis

2033-24-1
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367-25-9
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243448-16-0
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$90.00/100mg

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372-39-4 Synthesis

372-39-4
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243448-16-0
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$90.00/100mg

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