6-AMINO-1-ETHYL-1H-PYRIMIDINE-2,4-DIONE synthesis
- Product Name:6-AMINO-1-ETHYL-1H-PYRIMIDINE-2,4-DIONE
- CAS Number:41862-09-3
- Molecular formula:C6H9N3O2
- Molecular Weight:155.15
625-52-5
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$35.00/25g
372-09-8
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$20.00/25g
41862-09-3
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$60.00/500mg
Yield:41862-09-3 100 g (65%)
Reaction Conditions:
with sodium hydroxide;acetic anhydride in water;
Steps:
1.a a.
a. Preparation of 6-amino-1-ethyl-2,4-(1H,3H)-pyrimidinedione II To a solution of 127.5 g (1.5 mol) cyanoacetic acid and 200 ml of acetic anhydride was added 120 g (1.36 mol) of ethylurea. The solution was stirred at 60°-70° C. for 2 hours. After cooling, white crystals were filtered off and washed with ethanol. Yield 153 g (74%) (I). This was stirred in 1 liter of hot water and 160 ml of 2 N NaOH was added in portions so the solution the whole time was basic. The reaction mixture was refluxed for 20 minutes and then neutralized with 5 N HCl. After cooling, white crystals were filtered off. Yield 100 g (65%) (II) NMR.
References:
US4338319,1982,A
625-52-5
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$35.00/25g
105-56-6
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$10.00/5ml
41862-09-3
33 suppliers
$60.00/500mg
![2-cyano-N-[(ethylamino)carbonyl]acetamide](/CAS/GIF/41078-06-2.gif)
41078-06-2
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41862-09-3
33 suppliers
$60.00/500mg