6-Amino-2-phenyl[1,2,4]triazolo[1,5-a]pyridine synthesis
- Product Name:6-Amino-2-phenyl[1,2,4]triazolo[1,5-a]pyridine
- CAS Number:31052-93-4
- Molecular formula:C12H10N4
- Molecular Weight:210.23
![Carbamic acid, N-(2-phenyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/1428747-17-4.gif)
1428747-17-4
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31052-93-4
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Yield:31052-93-4 100%
Reaction Conditions:
with hydrogenchloride in diethyl ether at 25; for 18 h;
Steps:
1.c
c) 2-Phenyl-[ 1 ,2,4] triazolo[ 1 ,5-a]pyridin-6-ylamineA mixture of 2-phenyl-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-carbamic acid tert-butylester (1.04 g, 3.35 mmol) and hydrochloric acid (5 molar in diethyl ether, 20 ml, 100 mmol) was stirred for 18 hours at 25 °C. The solvent was evaporated, the yellow residue was made basic using saturated aqueous sodium hydrogencarbonate and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate, filtrated and evaporated to dryness affording 2-phenyl-[l,2,4]triazolo[l,5-a]pyridin-6-ylamine (715 mg, quant.) as yellow solid. Mp.: 201°C. MS: m/z=210.9 (M+H+).
References:
WO2013/41472,2013,A1 Location in patent:Page/Page column 26
1072-97-5
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31052-93-4
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100-47-0
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31052-93-4
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$452.62/250mg
![6-BROMO-2-PHENYL-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE](/CAS/20180601/GIF/86843-98-3.gif)
86843-98-3
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31052-93-4
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$452.62/250mg