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368426-75-9

(6-AMinoMethyl-1H-indazol-3-yl)aMine synthesis

2synthesis methods
105942-08-3 Synthesis
4-Bromo-2-fluorobenzonitrile

105942-08-3
378 suppliers
$7.00/5g

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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 6 h / 80 °C
2.1: hydrazine hydrate / butan-1-ol / 16 h / Reflux; Inert atmosphere
2.2: 6 h / Cooling
2.3: 2 h

References:

Dianati, Vahid;Navals, Pauline;Couture, Frédéric;Desjardins, Roxane;Dame, Anthony;Kwiatkowska, Anna;Day, Robert;Dory, Yves L. [Journal of Medicinal Chemistry,2018,vol. 61,# 24,p. 11250 - 11260]