6-aminospiro[3.3]hept-2-ylamine dihydrochloride synthesis

Yield:27259-95-6 57%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 20; for 4 h;

Steps:

2 COMPOUND 13

(6-Amino-spiro[3.3]hept-2-yl)-carbamic acid tert-butyl ester 12 (100 mg, 0.442 mmol) was added to 4N HCl in dioxane (4 mL) and the resulting mixture was stirred at rt for 4 hrs. The resulting suspension was carefully filtered and washed with Et₂O to afford 13 (50 mg, 57%) as the dihydrochloride salt and having the appearance of a white solid. ¹H NMR (400 MHz, CDC1₃) δ 8.27 (s, 6H), 3.50-3.54 (m, 2H), 2.33-2.39 (m, 2H), 2.14-2.22 (m, 6H).

References:

WO2017/160926,2017,A1 Location in patent:Paragraph 0181