ChemicalBook CAS DataBase List 6-Benzoylamino-9H-purine-9-acetic acid

6-Benzoylamino-9H-purine-9-acetic acid synthesis

7synthesis methods

Product Name:6-Benzoylamino-9H-purine-9-acetic acid
CAS Number:171486-04-7
Molecular formula:C14H11N5O3
Molecular Weight:297.27

Ethyl 2-(6-benzamido-9H-purin-9-yl)acetate

171406-46-5
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171486-04-7
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Yield:171486-04-7 1.4 g (95%)

Reaction Conditions:

with NaOH in water;

Steps:

Monomer Synthesis

N⁶-Benzoyl-9-carboxymethyladenine (4). Compound 9 (1.63 g, 5 mmol) and NaOH (0.4 g, 10 mmol) were dissolved in water (20 mL) and the solution was stirred for 2 h at room temperature. The pH was adjusted to 3 using 1 M HCl, causing precipitation of the product. The precipitate was separated by filtration, washed with water, and dried in vacuo to give 4 as a white solid: yield 1.4 g (95%); MS(+ESI): m/z 298 [M+H]⁺; ¹H NMR (400 MHz, d-DMSO): δ11.682 (s, 1H), 9.11 (s, 1H), 8.81 (s, 1H), 8.52 (s, 1H), 8.09 (d, 2H, J=7.2 Hz), 7.67 (t, 1H, J=7.2 Hz), 7.60 (t, 2H, J=7.2 Hz), 5.16 (s, 2H); ¹³C NMR (400 MHz, CDCl₃): δ169.43, 166.34, 152.89, 152,09, 150.29, 145.63, 133.74, 132.98, 128.45, 122.56, 44.88.

References:

US2011/245458,2011,A1

134461-75-9 Synthesis