6-benzyl-6-azabicyclo[3.2.1]octan-3-one synthesis

Yield:16607-47-9 68%

Reaction Conditions:

with manganese(IV) oxide in dichloromethane; for 2 h;

Steps:

1 6-Benzyl-6-azabicyclo [3.2. 1] octan-3-one

To a solution of 5- (benzylaminomethyl) cyclohex-2-enol (3.80 g, 17.5 mmol) in dry dichloromethane (150 ml) was added activated manganese dioxide (18.0 g, 210 mmol) in one portion. The mixture was stirred vigorously under nitrogen for 2 h. The yellow solution was filtered through Celite and the solids were washed with dichloromethane (2 x 50 ml). The combined filtrates were concentrated by rotary evaporation to give an orange oil, which solidified on brief standing. The solid was recrystallized from hot hexane/ether to afford the ketone as an off-white solid (2.6 g, 68%)

References:

WO2005/37832,2005,A2 Location in patent:Page/Page column 68