6-(benzyloxy)-2,3-dihydroinden-1-one synthesis
- Product Name:6-(benzyloxy)-2,3-dihydroinden-1-one
- CAS Number:25083-80-1
- Molecular formula:C16H14O2
- Molecular Weight:238.28
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Yield:25083-80-1 92.2%
Reaction Conditions:
with Cs2CO3 in N,N-dimethyl-formamide at 20 - 25; for 3 h;
Steps:
94.1 6-(Benzyloxy)-2,3-dihydro-1H-inden- 1-one
To the stirred solution of 6-hydroxy-2,3-dihydro-1H-inden-1-one (4 g, 27.0 mmol) and Cs2CO3 (6.77 g, 35.1 mmol) dissolved in DMF (5 mL) was added benzyl bromide (3.21 mL, 27.0 mmol) slowly at RT and stirred at same temperature for 3 h. After completion of reaction was quenched with water and extracted with ethyl acetate and purified by column chromatography to give the pure compound 6-(benzyloxy)-2,3-dihydro- 1 H-inden- 1-one(5.96 g) as white solid. Yield: 92.2 %; 1H NMR (300 MHz, CDC13): 7.34-7.46 (m, 6H),7.27-7.29 (m, 2H), 5.10 (s, 2H), 3.09 (t, J= 5.1 Hz, 2H), 2.73 (t, J= 5.4 Hz, 2H); MS (mlz):239.4 [M + H].
References:
WO2015/28960,2015,A1 Location in patent:Page/Page column 136; 137
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