6-BENZYLOXYMETHYL-4-HYDROXYPYRIMIDINE synthesis
- Product Name:6-BENZYLOXYMETHYL-4-HYDROXYPYRIMIDINE
- CAS Number:188177-37-9
- Molecular formula:C12H12N2O2
- Molecular Weight:216.24
67354-34-1
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3473-63-0
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188177-37-9
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Yield:-
Steps:
1.i i
After H2 evolution had ceased, formamidine acetate (2.31 g, 22.2 mmol) was added at 0° followed by dropwise addition of ethyl 4-benzyloxyacetoacetate (3.5 g, 14.81 mmol) and stirring was continued at rt for 3 d then at reflux temperature for 5 h. The methanol was removed under reduced pressure and the remaining yellow solid was partitioned between ether and water and the resulting ether extract discarded. Then aqueous layer was neutralized with acid and extracted with ether (*3). Concentration of the combined extracts afforded a crude solid which was triturated with hot ether to give white solid. (2.085 g, 65%)
References:
US5942516,1999,A