6-BROMO-1,2,4-TRIAZINE-3,5-DIAMINE synthesis

Yield:104405-59-6 84.6%

Reaction Conditions:

with potassium permanganate;ammonia at -30; for 1 h;

Steps:

6 Example 6Preparation of 3,5-diamino 6-bromo-1,2,4-triazine (Compound III)

0.15 mol of potassium permanganate was dissolved in 200 mL of liquid ammonia (-30 ° C), and 3-amino-6-bromo-1,2,4-triazine (2.625 g, 0.015 mol) was added dropwise with stirring. The reaction was allowed to proceed at -30 ° C for 1 hour, then ammonia was removed in vacuo, and the reaction product was extracted with 100 mL of propanol and dried in vacuo to give the product 3,5-diamino 6-bromo-1,2,4- The triazine was 2.41 g, and the yield was 84.6%.

References:

CN108129409,2018,A Location in patent:Paragraph 0046; 0047; 0048