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6-Bromo-1H-quinoline-2,4-dione synthesis

3synthesis methods
95262-09-2 Synthesis
4'-BROMOACETOACETANILIDE

95262-09-2
26 suppliers
$24.00/100mg

6-Bromo-1H-quinoline-2,4-dione

138964-51-9
20 suppliers
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Yield:138964-51-9 90 g

Reaction Conditions:

with methanesulfonic acid;phosphorus pentoxide at 50 - 72; for 2 h;

References:

Haffner, Curt D.;Becherer, J. David;Boros, Eric E.;Cadilla, Rodolfo;Carpenter, Tiffany;Cowan, David;Deaton, David N.;Guo, Yu;Harrington, Wallace;Henke, Brad R.;Jeune, Michael R.;Kaldor, Istvan;Milliken, Naphtali;Petrov, Kim G.;Preugschat, Frank;Schulte, Christie;Shearer, Barry G.;Shearer, Todd;Smalley, Terrence L.;Stewart, Eugene L.;Stuart, J. Darren;Ulrich, John C. [Journal of Medicinal Chemistry,2015,vol. 58,# 8,p. 3548 - 3571] Location in patent:supporting information