6-Bromo-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine synthesis
- Product Name:6-Bromo-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine
- CAS Number:426825-66-3
- Molecular formula:C13H8BrFN2
- Molecular Weight:291.12
Yield:426825-66-3 63%
Reaction Conditions:
with copper dichloride in 1,2-dichloro-ethane at 90;Inert atmosphere;
Steps:
Typical experiment procedure for the synthesis of imidazoheterocycles
General procedure: A mixture of 2-aminopyridines 1 (0.2 mmol), oxime esters 2 (0.24 mmol) and anhydrous CuCl2 (0.02 mmol) in dry DCE (1.5 mL) under nitrogen atmosphere was heated in oil bath at 90 °C. The reaction was monitored by TLC. After reaction was finished, it was quenched with water, extracted with ethyl acetate (3 x10 mL) and dried over Na2SO4. The combined filtrate was concentrated under reduced pressure to leave the crude mass which was purified by silica-gel column chromatography technique (hexane/ethyl acetate = 70:30) to afford the desired imidazoheterocycles 3.
References:
Gudimella, Santosh K.;Kaur, Amanpreet;Kumar, Ram;Samanta, Sampak [Tetrahedron Letters,2020,vol. 61,# 31,art. no. 152147] Location in patent:supporting information
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