6-BROMO-2-METHYL-4-NITRO-1H-BENZO[D]IMIDAZOLE synthesis
- Product Name:6-BROMO-2-METHYL-4-NITRO-1H-BENZO[D]IMIDAZOLE
- CAS Number:713530-56-4
- Molecular formula:C8H6BrN3O2
- Molecular Weight:256.06
84752-20-5
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Yield:713530-56-4 99%
Reaction Conditions:
with hydrogenchloride in ethanol;water; for 1 h;Heating / reflux;
Steps:
K K. 6-Bromo-2-methyl-4-nitro-1(3)H-benzimidazole;
K. 6-Bromo-2-methyl-4-nitro-1(3)H-benzimidazole; To a suspension of 65 g (0.28 mol) 4-bromo-6-nitro-1,2-phenylenediamine in 600 ml ethanol were added 140 ml 5N hydrochloric acid. The reaction mixture was refluxed and 58 ml (0.56 mol) of 2,4-pentanedione were added in one portion. After 1 h, the mixture was cooled down, poured into 500 ml water and neutralized with conc. ammonia. The precipitate was collected, washed thoroughly with water and dried over phosphorus pentoxide to give 70.8 g (99 %) of the title compound as a white solid. m.p. 229-231 °C.
References:
WO2004/87701,2004,A1 Location in patent:Page 39
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