6-broMo-2-naphthoyl chloride synthesis
- Product Name:6-broMo-2-naphthoyl chloride
- CAS Number:87700-60-5
- Molecular formula:C11H6BrClO
- Molecular Weight:269.52
5773-80-8
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Yield:87700-60-5 100%
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane;
Steps:
2.6b.1
6-bromo-2-naphthoic acid (72.3 g, 282 mmol, 1.0 equiv.) was suspended in dichloromethane (600 mL) and DMF (catalytic, 5 drops) was added. Oxalylchloride (71.6 g, 564 mmol, 2.0 equiv.) was added portion wise during 1 hour. The reaction mixture was stirred overnight with a CaCl2 drying tube mouthed on the flask. Complete dissolution occurred. The reaction mixture was concentrated, dichloromethane (100 mL) was added and the solvent was evaporated again, yielding 6-bromo-2-naphthoyl chloride (76.1 g, 100 %) as an oil which was used as such in next step.
References:
WO2011/54834,2011,A1 Location in patent:Page/Page column 38
79-37-8
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5773-80-8
301 suppliers
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87700-60-5
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