6-Bromo-2-oxo-1,2-dihydro-3-quinolinecarbonitrile synthesis
- Product Name:6-Bromo-2-oxo-1,2-dihydro-3-quinolinecarbonitrile
- CAS Number:99465-03-9
- Molecular formula:C10H5BrN2O
- Molecular Weight:249.06
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Yield:-
Reaction Conditions:
with bromine in acetic acid;
Steps:
51 3-Cyano-6-bromo-2-(1H)-quinolone STR182
PREPARATION 51 3-Cyano-6-bromo-2-(1H)-quinolone STR182 A suspension of 3-cyano-2-[1H]-quinolone (13.3 g) in acetic acid (130 cm3) was treated at room temperature with a solution of bromine (4.1 cm3) in acetic acid (10 cm3). After heating under reflux for 4 hours the mixture was cooled to room temperature, filtered, and the solid washed with ethanol to give 3-cyano-6-bromo-2-[1H]-quinolone (14.63 g), a small quantity of which was recrystallized from ethanol, m.p. 308°-311°. Analysis %: Found: C, 48.6; H, 2.1; N, 11.4. Calculated for C10 H5 N2 OBr: C, 48.2; H, 2.0; N, 11.3.
References:
US4710507,1987,A